For the normal functioning of the body, maintaining health and immunity, we need a large number of biologically active components, one of which is inositol. The substance is involved in the metabolism of fats, restores the reproductive system, improves the condition of the skin and hair. Without a natural compound, the antioxidant defense of the body is impossible, the absorption of nutrients, including B vitamins, suffers.
Inositol: what is it
Inositol (Inositol) - vitamin-like compound, which is often called vitamin B8, although, in fact, it is not. Proven that more than 75% daily requirement the substance is synthesized by the body itself from glucose and is included in the structure of tissues, therefore it makes no sense to talk about the absolute necessity of inositol.
Nevertheless, a lack of pseudovitamin in food can cause a lot of pathological conditions.
Inositol can be found in skeletal bones, liver and heart, retina, tears, and male semen. The substance structurally resembles a glucose molecule and is its isomer. Inositol chemical formula: C₆H₁₂O₆.
The daily requirement for a vitamin-like component largely depends on the state of the body. A large amount of natural compounds is required by athletes, people engaged in strenuous mental or physical labor, as well as schoolchildren and students. The need for inositol increases in depressive and stressful situations, since the substance is the main component of the tissues of the nervous system.
Indications for the use of inositol
There are many people for whom vitamin B8 is vital for the treatment and prevention of existing diseases. Most often, Inositol is included in the complex therapy of the following ailments:
- polycystic ovary syndrome (PCOS);
- infertility in women;
- type 2 diabetes, increased insulin production;
- chronic liver disease;
- neurological disorders;
- PMS symptoms;
- manifestations of dementia;
- insufficient or poorly balanced nutrition.
The use of inositol is widespread in neurosurgical practice for the recovery of patients after cerebral stroke.
Role in the body
The biological functions of pseudovitamin are difficult to overestimate. The substance is directly involved in many vital processes and is responsible for the normal functioning of all tissues and organs.
It is interesting. Just four cups of black coffee reduces the amount of inositol in the body by almost a quarter.
So, what is the role of vitamin B8:
- improves ovarian function;
- stimulates the regeneration of mitochondria;
- controls lipid metabolism, participating in the prevention of fatty liver hepatosis;
- accelerates the conduction of neuroimpulses, stimulates mental activity, memory and attention;
- strengthens the cell membrane, protects against destruction and penetration of pathogens;
- relieves eye fatigue and prevents various pathologies of the organs of vision;
- improves the functioning of the heart and blood vessels, prevents rhythm disturbances;
By contributing to the normalization of lipid metabolism, inositol prevents atherosclerosis, protects arteries from the appearance of plaques, fights obesity, hypertension and thrombophlebitis, and facilitates the course of osteochondrosis.
With its antidepressant effect, vitamin B8 reduces anxiety, eliminates anxiety, improves sleep and prevents depression. Inositol is recommended to be taken for various phobias, panic attacks, stressful situations.
Numerous studies have found good anti-cancer properties of pseudovitamin - the substance is able to prevent the development of cancer in the intestines, lungs, mammary gland, skin and liver.
The effect of inositol is markedly enhanced when combined with another B vitamin - choline. Find out what this substance is and how to take it correctly,.
Inositol use
Vitamin B8 was discovered by the German chemist Justus von Liebig in 1848. However, a worthy use of the useful substance was found much later - only in the middle of the 20th century, inositol began to be used as a membrane protector and lipotrope.
It is interesting. Mobilization of fat from the liver and its oxidation under the influence of inositol is especially effective with a low-calorie diet, as well as in the presence of vitamin E.
Several years later, they found that the amount of inositol in the blood of people with diabetes mellitus was significantly reduced. This led to the idea of the need to include the substance in the complex therapy of the disease.
Inositol for men
Vitamin B8 is the strongest regulator and stimulator of human reproductive activity. In the stronger sex, this is expressed by maintaining erectile function, improving the quality of seminal fluid and normalizing hormonal levels.
Attention. A sufficient amount of inositol in the body is the best prevention of male infertility and diseases of the reproductive system - inflammation and prostate adenoma, vesiculitis, urethritis.
Benefits for women
For women, vitamin B8 is recommended to be taken as prevention and treatment of insomnia, all kinds of psychosomatic disorders, anxiety, eating disorders (gluttony), premenstrual syndrome.
The benefits of inositol for women do not end there. The organic component activates all metabolic processes in the body, therefore it is often taken for losing weight and improving the condition of the skin. Pseudovitamin is especially useful for unclean dermis prone to rashes and age spots.
Inositol is also irreplaceable for hair. The substance not only stimulates the growth of curls and makes them strong, but also fights hair loss, protects against alopecia.
Vitamin B8 is recommended to be applied externally to improve the health of the hair and scalp. For home care products, it is better to purchase inositol in powder and add to masks, shampoos and rinses. This will give the curls a wonderful shine and smoothness, make it easier to comb and prevent breakage.
Inositol for IVF
The use of vitamin B8 supplementation is especially common in IVF practice, increasing the chances of IVF success. A good therapeutic effect is provided by an integrated approach to treatment.
Attention. Inositol shows a particularly tangible result with IVF for age couples, increasing the percentage of conception from the first time by 30-40%.
Vitamin B8 in cancer treatment
Information on the effectiveness of inositol as an inhibitor of malignant tumors is often found on the Internet. The most successful in this regard is the research of the professor of pathology from the University of Maryland Abulkalam M. Shamsuddin.
After performing many experiments on animals, the doctor discovered that one of the derivatives of inositol - hexaphosphate (IP6) - exhibits strong antitumor properties, but does not destroy cancer cells, but returns them to their normal state, thereby preventing the danger they pose.
These conclusions were confirmed and supplemented by a number of subsequent experiments. Scientists have shown that inositol reduces the risk of developing cancer by 60% compared to other tested compounds.
The statistics collected by American scientists over the past 20 years are very interesting. During long-term follow-up, it was revealed that the incidence of cancer in Asian countries is no less than Western cultures, but it is in Europe that cancer tends to progress and recur, while in the East this does not happen.
Why is that? The results of the study, cited in the scientific journal US Cancer Prevention Research, showed that it was all about eating a lot of vitamin B8.
What foods contain inositol
This organic compound comes to our table from plant and animal sources. To maintain vital functions, a healthy person must consume at least 1000 mg of the substance per day.
Where is inositol found? This organic element can be found in almost all foods: milk, meat, vegetables, cereals and drinks.
Attention. In plant foods, vitamin B8 is present in the form of hexaphosphate. Most of the substance is in bran and wheat germ.
The table will help you remember which foods contain inositol.
| Sources of Inositol | The amount of vitamin B8, mg / 100 g. |
| Sprouted wheat | |
| Rice bran | |
| Barley groats | |
| Oatmeal | |
| Peas | |
| Oranges | |
| Roasted peanuts | |
| Grapefruit | |
| Lentils | |
| Raisin | |
| Melon | |
| Peaches | |
| White cabbage | |
| Potato | |
| Watermelon |
The table shows that there is not so much vitamin B8 in food. To get your daily dosage of the nutrient, you will have to eat almost 3 cups of oatmeal or a large melon. And cow's milk, in 100 g of which contains only 17 mg of inositol, will need almost 6 liters.
Therefore, it is easier to compensate for the lack of an organic component with the help of special additives containing inositol.
Vitamin B8 deficiency symptoms
If the diet lacks inositol-rich foods or is excessively addicted to alcohol or caffeine, a deficiency of the substance may occur. Symptoms of vitamin B8 deficiency are manifested as follows:
- deterioration of vision;
- depression, irritability, bad dream, fatigue;
- thinning hair;
- the appearance of spots and rashes on the skin;
- upset stool (constipation);
- problems with the heart and blood vessels.
Physical and mental development slows down in children and adolescents, and school performance decreases. In women, fertility problems and infertility are possible.
The lack of a substance impairs the absorption and work of other B vitamins.
Contraindications and side effects
Inositol is a fairly safe oral supplement. All undesirable reactions associated with it are manifested by mild bowel disorders when high doses are used.
Among the contraindications, one can especially highlight the individual intolerance of the vitamin and the period of pregnancy.
There were no side effects from the interaction of inositol with other medications. Moreover, the substance significantly improves the absorption of other B vitamins and becomes the basis for the formation of lecithin.
Myo-inositol and inositol: what is the difference
What is the difference between inositol and myo inositol? The term "inositol" contains 9 stereoisomers - molecules with the same structure. Myo-Inositol is the main and only active form of inositol, that is, part of it.
Myo-inositol is considered an important transmitter of neurosignals in the intracellular signal cascade. The stereoisomer is involved in the conduction of impulses from insulin receptors, lipid breakdown, regulation of intracellular calcium (Ca2 +), and a decrease in blood cholesterol concentration.
Attention. Myo-inositol is found in many foods, but the tables provided for information rarely distinguish between the active isomer of inositol and phytic acid, its low activity form.
Inositol when planning pregnancy: how to take it right
Today, 10% of young women are diagnosed with PCOS (polycystic ovary syndrome). This disease develops against a background of hormonal disorder and is manifested by anovulation, weight gain, high testosterone levels and an inability to get pregnant.
The use of myoinositol for infertility restores ovulation, reduces the level of testosterone and triglycerides in the blood, and improves the functionality of the ovaries. More than 70% of women who drank inositol were able to conceive.Important. Laboratory studies conducted in Italy have shown that the combination of inositol and folic acid increases the percentage of conception in women with PCOS, especially the elderly.
How To Take Vitamin B8 For Results? Experts recommend using 4 g of inositol daily when planning pregnancy. You should drink regardless of the monthly cycle. It is good to supplement pseudovitamin with folic acid and methionine.
Can I drink Inositol during pregnancy? Here the opinion of scientists differs. Some experts claim that during the period of bearing a child, 1 g of the substance should be taken daily.
Vitamin improves blood circulation in the uterus and has a beneficial effect on the development of the fetus, is the prevention of neural tube underdevelopment and Down's disease. In addition, if a woman is diagnosed with diabetes mellitus, inositol maintains an optimal concentration of glucose in the blood.
Opponents oppose the use of vitamin B8, justifying their position by the fact that the substance affects the uterus like oxytocin, causing its hypertonicity and contraction.
Therefore, the use of large doses of inositol can be harmful, but the recommended amount of the substance will be useful for both the mother and the child.
Vitamins are essential for maintaining health. Feeling unwell often speaks precisely of the lack of any substance in the body. Vitamin deficiency is especially acute in late autumn and early winter. Today we will look at the B vitamin, inositol, in the common people its name sounds like B8. What it contains, how much of it should be consumed per day, how to determine the lack of this vitamin in the body and how it is so beneficial for health, we will figure it out in this article.
Description and general characteristics
The full name of the substance sounds like inositdroretinol, reductions to inositol or inositol are possible. All this is known to us
This substance - powder substance, which has a crystalline structure and has a pleasant, slightly sweet taste. Inositol can be easily dissolved in water, but alkaline solutions and acids will not have a dissolving effect. Heat can destroy the structure of a substance.
Did you know? The discovery of inositdroretinol belongs to the German chemist Liebig. This event happened in the middle of the 19th century, but only eighty years later, inositol entered the group of B vitamins, where it is listed to this day, despite the fact that inositol is a vitamin-like substance.
In the human body, a high level of inositroretinol is characteristic of the brain, tissues of the central nervous system, as well as the lens of the eye and blood. In addition, such biological fluids as lacrimal and seminal fluids contain inositol.
For the production of vitamin B8 in the body, organs such as the heart, intestines, liver, and also the kidneys are responsible. It is important to understand that if a person has problems with the work of the listed organs or even their diseases, inositol will be synthesized in a smaller amount and you will have to replenish the level of the substance with the help proper nutrition or pharmaceutical preparations such as vitamin complexes.
It is because of the production of a substance by the body itself, inositroretinol is not a vitamin. However, its role in maintaining health is important enough to include inositol as a vitamin. An adequate supply of glucose into the blood plays an important role in the production of inositol in the body.
Main functions and benefits for the body
Like all trace elements, inositol has a positive effect on the vital functions of the body. Due to the normal level of inositol in the body, you can protect yourself from diseases of internal organs and just strengthen the immune system. Let's take a closer look at why it is so important to take inositroretinol and what is its role in maintaining our health.
For health
Several years after the discovery of inositdroretinol, it became clear that how is it useful: inositol contributed to the normal course of metabolic processes in the body, was a part of many enzymes, activated the so-called lipid metabolism, due to which fat is burned in the body.
Inositol is an irreplaceable element of its group of vitamins. Deficiency of a vitamin-like substance leads to that the body disrupts the normal course of many processes. Its presence stimulates mental activity, the work of the brain, allows better concentration of attention, increases the threshold of brain fatigue and the ability to memorize information.
The use of vitamin B8 is necessary in the treatment of disorders of the sensitivity of nerve endings, since inositol is a substance that ensures the transmission of impulses from cell to cell. In addition, the effect of toxins, alcohol, antibiotics and hormonal substances on the liver, as well as the growth of fatty tissue around it, is blocked or reduced precisely due to the presence of B8 in the body, and its antioxidant effect allows you to remove harmful free radicals from the body.
Inositol is also involved in the maintenance of reproductive functions in both men, by stimulating the reproduction of sperm, and in women, by stimulating the division of the egg. One of the reasons for infertility may be precisely the deficiency of this vitamin.
Blood is a "transport" for B8 and delivers it to those parts of the body where it is needed. As a rule, most often it is the retina and lens of the eye.
For the influence of inositol on the metabolism in the body, the efficiency of the liver and the condition of the skin and hair, it is called the "vitamin of beauty".
For skin
Inositroretinol has a positive effect on the appearance of the skin. If the level of this vitamin in your body is normal, you do not have to worry - all kinds of diseases associated with the skin do not threaten you. If you notice that the skin color has become dull or vascular networks are visible, you can safely resort to the help of inositol. It will strengthen the health of the skin.
In addition, a vitamin-like powder- a good antioxidant, thanks to which it is possible to remove toxins, including from the skin.
For hair
Vitamin B8, or inositol, is essential for your body. Thanks to him, the hair follicles become stronger, stopping hair loss, and the hair itself ceases to be dry and brittle. That is why B8, otherwise called the "beauty vitamin", is found in hair and skin care products.
With inositol deficiency, your hair will become dull, brittle, and hair loss may begin. To prevent hair problems, it is recommended to regularly take vitamin complexes, which include B8. Restoring the vitamin balance in your body will allow you to get rid of many problems, including those with hair, but it is worth remembering that the use of inositroretinol will not bring an instant effect.
If you want to see the result "here and now", then you can apply vitamin B8 topically- There are many cosmetics containing this vitamin-like substance, which begin to act when applied to the hair. It is best to buy the "beauty vitamin" in powder form, which is added to shampoos, balms and other hair care products. As a result of using these products, your hair will no longer be brittle and dull, it will become easier to comb and hair loss will stop.
Inositol can be obtained not only from vitamin complexes, but also from ordinary food that we eat every day. If signs of B8 deficiency appear, it is worth starting to eat foods containing this vitamin in the required amount.
Did you know? A serving of chili peppers contains 400 times more vitamin C than a serving of oranges.
Inositdroretinol, in addition to the qualities already mentioned, able to eliminate stress, which always negatively affects the condition of your skin and hair. Inositol accumulates in cell membranes located in the spinal cord and brain, and if there is enough of it, the nervous system of your body will be quickly restored, and your hair will not be at risk of hair loss or other problems.
The recommended course of application of vitamin B8 in the presence of problems with the scalp - 2 weeks or more, if necessary, the course is repeated every 4-6 months. External use of the "beauty vitamin" does not require special permission or consultation with a doctor and is completely harmless.
Sources of vitamin
A large part of inositol is produced by organ gp - more than 70%, but this does not mean that you should neglect foods that are rich in vitamin B8. The inclusion of this food in the diet will help to replenish the reserves of inositroretinol, and will also help fight vitamin deficiency if you have symptoms of vitamin deficiency in your body.
Important! Do not forget that at high temperatures the vitamin-like substance will begin to break down, therefore, when cooking, it is best to use a method such as steaming or baking if the product is not eaten raw. These methods will help minimize the loss of a nutrient.
Eating a small amount of any of the following foods once a day is sufficient to keep your inositol levels normal. This will be an excellent prophylaxis to help avoid hypovitaminosis.
Vegetable
To obtain inositroretinol from plant products, you must have in your diet:
- sesame oil;
- raisins;
- barley groats;
- wheat bran or germ;
- brewer's yeast;
- peaches;
- rice bran.
Animals
Vitamin B8 is mostly found in plant products, but this does not exclude its content in meat and animal products. The presence of inositol is typical for the following products:
- beef heart;
- beef brains;
- kidney;
- veal;
- calf liver;
- pork;
- breast milk;
- chicken meat;
Daily requirement and rate
People who have already taken vitamins know why it is impossible to exceed the specified norm of the substance. Despite all the benefits that trace elements bring to your health, exceeding the norm can lead to tissue intoxication, since in large quantities some useful substances are toxic.
Important! The need for inositol increases if your diet often contains caffeinated foods or alcoholic beverages. Also, the reason for increasing the dose of the vitamin may be the weakening of the immune system due to the intake of antibiotics. Another reason is the heavy load, both physical and related to the work of the brain.
Inositroretinol cannot be classified as a toxic substance, however, the required minimum, which must be present in your diet, you need to know. This will help prevent the deficiency of the substance in time, or even help you understand the cause of the origin of the symptoms of vitamin B8 deficiency, and therefore, cope with it by increasing the substance in the daily diet.
For adults
In total throughout the day for a healthy person no more than 2 g of inositroretinol is needed. Let's not forget that this substance is produced by the body, so it is enough to get about 0.5-1 g from food or by taking medications. You can increase the rate if your health is not in excellent condition.
For kids
The child's body is enough get 0.5 g of vitamin B8 per day to replenish the need for inositol. As in adults, the body of children is also capable of synthesizing this substance, therefore a large number vitamin is not required. It is advisable for adolescents to eat more foods containing inositroretinol, since the substance contributes to the development of the body, and its lack can inhibit this process.
Lack and excess
The lack of a vitamin-like substance can often be guessed by external factors. After all, inositroretinol is involved in many life processes, and its deficiency can cause decrease in physical and mental activity, rapid fatigue, insomnia, absent-mindedness, and cases of deterioration in the ability to memorize information are not excluded.
At the physical level, constipation, liver problems, poor circulation, increased blood pressure and cholesterol levels are possible.
In addition, the lack of inositroretinol contributes to the deterioration of the body's ability to obtain nutrients from foods. That is, all trace elements and vitamins contained in food will not be absorbed, which means they will not be able to positively affect your health.
Important! Specifically, inositroretinol is also responsible for metabolism, and an insufficient amount of the substance will contribute to rapid weight gain up to obesity.
For child's body isositol deficiency is fraught with stopping the development of the body, including cessation of growth, as well as muscle dystrophy.
Inositroretinol also affects the mental state of a person. With a lack of vitamin, inexplicable fears may appear, a person will be irritated more often than usual, and may even become depressed.
As for the overabundance of inositroretinol, then B8 is characterized by low toxicity, in connection with which the use of many vitamins must be controlled in order to avoid the spread of toxic substances to tissues and internal organs. Consuming more inositol than needed will not lead to similar consequences. The most you can get- this is the appearance of an allergic reaction to an excess of a substance. Most often it is expressed in the form of rashes or redness on the skin.
Interaction with other substances
Before you include vitamin B8 in your diet, you need to find out which combination with which substances will bring the body the greatest benefit, and what is better to exclude, so as not to impair the absorption of this vitamin-like substance.
Products most often- drinks that contain caffeine contribute to the destruction of inositol. This leads to the fact that even by eating foods containing B8, you do not replenish the supply of this substance. Over time, there may be a lack of vitamin - we have already talked about the consequences of this.
Important! The sulfanilamide group of medicines can also destroy the structure of the vitamin-like substance, so we recommend that you consult with your doctor about taking inositol - you may need to increase its amount in your diet after a course of treatment with medications.
Various varieties (especially green) are characterized by the presence of caffeine, energetic drinks and some sodas like Coca-Cola. We do not ask you to completely abandon them, but it is better not to exceed daily rate at 300-350 mg (these are three small cups of coffee or five cups of tea).
To enhance the effect of inositol, you can simultaneously take other vitamins related to or E. Then B8 will be better absorbed by the body, which means that your health will be in order.
Pharmacy forms
Sometimes a person cannot include foods rich in inositol in his diet, therefore, jars from the pharmacy come to the rescue. Most often, you can find inositroretinol in powder form (it can also be used for external use), as well as tablets and gelatin capsules.
Are there any contraindications
Inositol is versatile. This substance, as a rule, does not cause allergies, and also does not have a negative effect on human health. For this reason, it is B8 that everyone, without exception, can use - both adults and children.
Polycystic Ovary Syndrome or PCOS- one of the most common female diseases. It is because of polycystic disease that women lose their health, attractiveness and beauty. But ... for some reason they do nothing and perceive all the external signs of polycystic disease as cosmetic imperfections.
Only a healthy woman can radiate real beauty. If there are problems in the body, then no designer clothes, fashion accessories, branded decorative items, miracle shampoos, magic smears, epilation and depilation will make you really beautiful. The main adornment of any woman, what always remains with her is smooth clean skin, thick shiny hair, strong nails, a feminine figure and a blooming appearance even from early morning. Yes, the way you look in the morning without makeup and everything is your true beauty.
If there is no inner health, then what kind of beauty and grooming can we talk about? Smeared blackheads, oily hair and excess vegetation are abnormal, this should not be so and can disfigure even a written beauty. I agree that enhanced external care and timely hair removal will help you look decent, but what colossal physical, financial effort and willpower is worth maintaining yourself at a normal level, mind you, not to look gorgeous, but just normal. Now let’s direct all this effort and willpower to troubleshoot your beautiful female body. As a result, you will have a lot of free time, and you will always look 100%. And how to achieve this will be discussed in this post.
External signs of PCOS:
Lack of menstruation for a long time, infrequent or irregular periods. A stable and regular cycle of 28 days (+/- several days) is the basis of women's health
- daub before the onset of menstruation and in the middle of the cycle
- pulling pains in the lower abdomen and lower back
- excess vegetation of the male type. If you are growing noticeable hair on your face, chest, and abdomen, it is a marker of body problems.
- oily skin, acne (acne, blackheads), blackheads and clogged pores.
- hair on the head falls out and gets greasy quickly
- dandruff, seborrhea
- central obesity (fat is concentrated in the abdomen, male type)
- mood swings, lethargy, depression, drowsiness, aggression
- androgenic alopecia (male pattern baldness)
- the appearance of seals in the chest (fibrocystic breast disease)
- lowering the timbre of the voice
Found a few signs? Then do not postpone a visit to the gynecologist-endocrinologist.
Be sure to do an ultrasound scan and donate blood for hormones - the correct diagnosis is made this way + external signs. If the doctor suggests you "drink OK for prevention", relying only on the results of the ultrasound - run. Seriously, you'd better leave such an incompetent doctor right away, before you get into trouble.
Ultrasound signs of PCOS:
Ovaries with many small cysts
- oligoovulation (no ovulation) or anovulation (rare ovulation)
- ovaries enlarged by 1.5-6 times
- thickening of the ovarian capsule
Signs of polycystic disease by laboratory tests:
Increased levels of male hormones androgens (free testosterone, DHT, DHEA-S, androstenedione), which circulate in the blood of every woman, but with PCOS their level goes off scale
- an increased level of luteinizing hormone (LH) or the ratio of LH / FSH
- low levels of the hormone progesterone in the 2nd phase of the cycle
- high fasting insulin
- low level of sex hormone binding globulin (SHBG, PSG, SHBG)
- insulin resistance index HOMA IR increased on an empty stomach
- in the GGT test (+ insulin), an increase in insulin after exercise by more than 3-5 times
- in the GGT test, glucose is below the fasting value
- fasting glucose is higher than normal
IMPORTANT! High total testosterone levels can be a personality trait for you and can affect your personality. But the appearance is affected only by free testosterone, an increase in which is observed in PCOS.
In polycystic disease, we also see a high level of IGF-1 (insulin-like growth factor), an increase in triglycerides, LDL (low density lipoprotein) and a decrease in HDL (high density lipoprotein).
The most harmful hormones that spoil women's beauty are androgens, insulin and IGF-1. Here they are the culprits of excess weight, oily skin, acne and other "imperfections", as they say in advertising. Globulin also plays a role, if its level is low, then it does not bind androgens and they circulate freely in the blood, more anrogens - more "imperfections".
Our goal is to reduce: the level of androgens, insulin, IGF-1, to increase: SHBG, insulin receptor sensitivity; resume: ovulation and normal cycle - hello beauty, youth, clear skin. And of course, find the real cause of your PCOS. Yes, I almost forgot, all this will help: increase fertility, the quality of eggs, lose weight (or gain weight), get pregnant and safely give birth to beautiful healthy babies :)
Causes of PCOS
PCOS- polyendocrine syndrome, which occurs due to disturbances in the work of the endocrine system and a number of other pathological conditions.
The causes of PCOS, dysfunction:
Ovary
- hypothalamus and pituitary gland
- insulin sensitivity of tissues and / or ovaries
- pancreas
- adrenal cortex
- thyroid gland
As well as:
Autoimmune mechanisms
- genetic and hereditary factors (the presence of PCOS in close relatives)
- chronic infectious diseases (even tonsillitis in childhood)
- pregnancy, childbirth with complications
- obesity
- abortion
There are several causes of PCOS.
Traditional conservative medicine "treats" polycystic disease with oral contraceptives (OC) with antiandrogenic activity.
How does OK work? They turn off the ovaries, put the body into a state of non-existent pregnancy, maintain an artificial hormonal background and cycle (contraceptive pills do not have their own periods - this is withdrawal bleeding).
And what is the result? While you are taking OK, the ovaries do not work and do not secrete hormones, you may look good (due to the artificial hormonal background), but your entire endocrine system is also working incorrectly, is in a certain state of prostration "what is happening?"
That is, OK only act on the consequence, create a picture of an imaginary external well-being. They do not eliminate any cause of polycystic disease, do not improve the work of the endocrine system, do not help the body to work properly. That's actually all the "treatment". This therapy is more than absurd.
Taking birth control pills aggravates existing problems with the work of the ovaries, thyroid gland, carbohydrate metabolism, etc. After the abolition of OK, the patients see that everything returns with a vengeance and PCOS is overgrown with new diagnoses. Someone does not have a cycle within a year, someone learns about alopecia, an increase in body weight, etc. And many beautiful ladies, again addicted to OK, than feed the pharmaceutical companies and finish off their poor health. I will not write about the side effects of taking OK, you can read any instructions yourself, I am terrified how people voluntarily and slowly kill themselves.
I do not argue that birth control pills can be contraceptive aids for women with good general and strong endocrine health. Such women have been drinking OK for years and remain healthy, although the long-term effects have not yet been studied. But can we count a woman with PCOS among them?
Today, the most progressive and safe method of treatment is to eliminate the causes of PCOS, to adjust the robot of the endocrine system in the most natural and natural way.
PCOS Protocol:
Nutraceuticals + drugs
- diet
- Lifestyle
- sports and physical activity
- emotional stability
Polycystic disease is a syndrome, it is reversible!
Below I will tell you about the therapy for PCOS caused by INSULIN RESISTANCE (IR) with the help of nutraceuticals. I'll start with 2 main ones: inositol + folic acid. Nowadays, advanced gynecologists prescribe a drug for women with PCOS. Inofert(as part of myo-inositol + folic acid), you can ask your doctor about it.
Myo-inositol
A basic nutraceutical for women with polycystic and IRR, the cause or one of the reasons for which:
Decreased tissue and / or ovarian insulin sensitivity
- disruption of the pancreas
- type 1 and 2 diabetes (especially type 2) or insulin resistance
Myo-inositol has scientifically proven efficacy for PCOS due to IR, as well as numerous clinical trials in women.
Inositol is the generic name for myo-inositol. If inositol is indicated in the composition, then you can be 99% sure that this inositol is presented in the form of myo-inositol.
Myo-inositol is a naturally occurring substance that is often regarded as one of the B vitamins. The body is able to produce inositol on its own. Modern research shows that in women with PCOS, there is a link between insulin and hormone levels, as well as inositol deficiency in the body.
How does myo-inositol work?
I will try to present theoretical information as accessible as possible.
Insulin affects the functioning of the entire body and is produced by special cells in the pancreas. Every cell in the body has a receptor that is sensitive to insulin (the ovaries too), the receptor and insulin fit together like a "lock" and "a key" (insulin is a "key" and a receptor is a "lock"). If the receptor becomes insensitive to insulin, then the "key" cannot open the "lock". The brain immediately receives the information: "Not enough insulin! It does not work! This is bad insulin! Come on more!" The release of insulin increases, and this immediately leads to a chain reaction - an increase in the production of male hormones androgens, such as testosterone, DHT and DHEA-S, and in the long term to metabolic disorders, endocrine system functioning, infertility and other bad consequences.
A simple visual video about the work of insulin and its receptors:
Myoinositol allows you to adjust the sensitivity of receptors to insulin. The body no longer produces too much insulin and androgens, and the metabolism improves. It happens that the level of insulin is normal, but the sensitivity of ovarian tissues to insulin is lowered - myo-inositol will help here.
Generally speaking, the action of inositol is somewhat similar to metformin, which is prescribed for type 2 diabetes or insulin resistance or PCOS. In the case of polycystic disease, myo-inositol acts more gently, better eliminates the signs of PCOS, has fewer side effects and is often prescribed by gynecologists in conjunction with metformin.
IMPORTANT!Before taking myo-inositol or drugs based on it, you need to make sure that your PCOS is caused by one of these reasons:
Decreased tissue and / or ovarian insulin sensitivity;
- disruption of the pancreas;
- type 1 and 2 diabetes (especially type 2) or insulin resistance
Take the necessary tests, consult with your gynecologist, and only then start taking something. As a last resort, write to me and I will tell you what tests you need to take and whether you need inositol.
And most importantly, they do not drink myo-inositol to improve the skin or just like that - this is a drug that affects many processes in your body, take good care of yourself :)
Clinically proven effects of myo-inositol in PCOS:
Decrease in free testosterone levels (up to 73%);
- an increase in low estrogen;
- improves insulin sensitivity;
- promotes weight loss;
- restores the normal menstrual cycle;
- increases the frequency of pregnancy;
- improves sleep and falling asleep;
- Increases peak progesterone (by 129% in one study);
- lowers the level of prolactin;
- restores normal ovulation;
- increases the rate of fertilization;
- has some calming effect;
- prevents such a congenital defect as spina bifida;
- reduces total testosterone (by 65%);
- decrease in LH (up to 55%);
- reduces the insulin response after a meal (by 62%);
- lowers DHEA-S (by 49%);
- increases sex hormone binding globulin (up to 92%);
- reduces androstenedione (by 27%);
- reduces the level of triglycerides (by 51%);
- lowers blood pressure (slight decrease);
- reduction of hair loss and improvement of scalp hair growth
Studies on the effects of inositol have also been shown to be effective for acne (up to 53% reduction), dandruff and hirsutism. Some girls even experience the loss of some unwanted body hair closer to the 6th month of taking myo-inositol.
Inositol improves hormonal, metabolic and ovarian function. Even if studies show a decrease in hormonal levels, myo-inositol rather normalizes them and brings them closer to ideal :)
Inositol is available in capsule and powder form. Clinical studies were conducted using 4 grams of myo-inositol per day + 400 mcg of folic acid.
IMPORTANT! According to the latest research, myo-inositol capsules are 30% more effective than powder inositol.
Myo-inositol powder:
Myo-inositol capsules:
With prolonged intake of folic acid, a strong increase in estrogen can be observed, therefore, control the level of the hormone and approach the intake of foil wisely.
IMPORTANT! About 40% of the population has mutations the MTHFR gene and ordinary folic acid are poorly absorbed or not absorbed at all. Pay attention to the highly digestible form of bioavailable folic acid - methylfolate... Folk in this form works for everyone.
The Italian drug Inofert is available in Russia and Ukraine, and a similar Inofem or Inofolic can be ordered on ebay. Each sachet contains a combination of myo-inositol and regular folic acid in the right amount. In 1 sachet of Inofer - 1 g of inositol and 100 mcg of foil, and in Inofem and Inofolic - 2 g of inositol and 200 mcg of folic acid. It is necessary to take several sachets to achieve 4 g of inositol and 400 mcg of foil, which is quite expensive, given the price of the drugs. The most profitable option is to take myo-inositol powder on your favorite iherb and buy folic acid separately.
Complex preparations based on inositol and folic acid:
2. Premama, Reproductive Support Supplement, Fertility, Unflavored, 28 Packets, 2.17 oz (62 g) sachets, analogue of inofert, inofolic, inoferm
Some women take lower (1-1.5 teaspoons or 1-2 capsules or 1-1.5 grams per day) or high doses of myo-inositol (usually increased to 6-8 grams per day).
IMPORTANT! 4 g is a dose of myo-inositol that has been proven to be effective in clinical studies, and even 1 capsule of 500 mg may work for you. Therefore, do not rush to take high doses of myoinositol.
IMPORTANT! Start taking inositol on the first day of your cycle, not in the middle. Since you can knock and break your cycle.
In the following parts I will talk about other causes of PCOS, nutraceuticals, lifestyle, sports, the best way to remove unwanted hair, cosmetics and PCOS care.
2nd part of the protocol, health and love to all :)
RZL600 code gives a 5% discount to all, all customers (the discount is added with any codes for all orders). Each time in the basket, when placing an order, enter the code RZL600 manually or follow any link from the article. I am pleased to see that the blog is useful and I am not writing here for nothing) You inspire me with your letters, thank you, my dear readers)All the proceeds will be used for research and the search for the most effective drugs: for the treatment and control of PCOS, improving skin and hair, prolonging youth and beauty :)
Myo-inositol is one of the varieties of inositol hexatomic alcohols. Inositol exists in nine possible stereoisomers, of which only one form is present in a living cell - myo-inositol. It is myo-inositol that acts as a transmitter of intracellular signals from the insulin receptor, participates in the breakdown of fats and lowering blood cholesterol levels and many other processes in the body.
Myo-inositol and its derivatives are found in fruits (melons, oranges), also in legumes, grains, and nuts. The taste of myo-inositol is less sweet than sucrose - approximately twice. In plants, inositol is found mainly in the form of phytic acid and its salts, phytates, which serve as a source of phosphates for the germinating seed. It should be noted that without preliminary treatment, phytic acid is poorly absorbed by the human body. In addition, phytates significantly reduce the bioavailability of minerals (calcium, magnesium, iron, zinc), increasing the risk of developing mineral deficiencies.
Myo-inositol was previously considered one of the B vitamins (vitamin B8). Later, when it was found that in a healthy person, myo-inositol is synthesized in the kidneys in an amount of several grams per day, it was no longer considered as a vitamin (an essential organic nutrient that is not synthesized in the human body). However, if a person has decreased kidney function or some other processes disrupt the synthesis of myo-inositol, then for that particular person, myo-inositol can be considered as a vitamin.
Myo-inositol and the reproductive system
Myo-inositol and its derivatives, necessary for the implementation of the effects of sex hormones (gonadotropin, luteinizing and follicle-stimulating hormones), affect the functioning of the reproductive system. The effect of myo-inositol on connective tissue is of fundamental importance for the healthy development of the embryo. As you know, polycystic ovary syndrome (PCOS) is one of the main causes of infertility. Patients with PCOS often have insulin resistance and impaired carbohydrate metabolism. Combination therapy of PCOS with the inclusion of myo-inositol reduces the risk of metabolic disorders by beneficially affecting the metabolic rate, the state of hormonal regulation and ovarian function.
Myo-inositol is involved in the normal functioning of the reproductive system and the development of the embryo, and is also necessary for the biological effects of folates and other vitamins and minerals that affect the course of pregnancy and the state of the mother-placenta-fetus system.
The effects of myo-inositol
The key mechanism of action of myo-inositol has been confirmed in clinical studies involving large numbers of women. The use of myo-inositol normalizes metabolic processes in the body (reduces insulin resistance and compensatory hyperinsulinemia), which leads to the restoration of normal hormonal parameters and, as a result, to:
resumption of ovulation;
resumption of menstruation.
According to the available data, there are no side effects when taking myo-inositol and taking myo-inositol is well tolerated. In one sachet Myofolic contains 2000 mg of myo-inositol.
There are few weight loss supplements that are actually effective or have scientific evidence to back it up.
Myo-inositol is one such dietary supplement, and it is effective for certain groups of people because it affects hormones and is a secondary messenger in cells (intracellular signaling molecule). The nutrient is used to treat sex hormone imbalances, PCOS, and mood disorders. Learn how to apply it correctly and effectively.
What is myo-inositol and what are its benefits for the body?
It is the first isolated form (isomer) of a vitamin-like substance (pseudovitamin). The nutrient was previously classified as a B vitamin due to its effects on brain tissue, stress and mood.
Myo-inositol helps regulate a number of cellular processes and is a critical part of membrane phospholipids, the protective barrier of every cell in the body.
The benefits of this nutrient are related to the effects on hormones in the human body. Obesity is often the result of hormonal imbalances. The same applies to PCOS - multiple hormonal imbalances in the body that cause various symptoms.
The beneficial properties of myo-inositol:
- Improves blood pressure.
- Reduces insulin resistance.
- Promotes weight loss by normalizing hormone levels.
- Increases the amount of "good" cholesterol (HDL).
- Reduces acne and hirsutism (male-pattern hair growth in women).
- Improves sleep.
- Reduces depression and other mood disorders.
- Increases fertility.
- Reduces PMS symptoms.
It is worth noting 2 important nuances regarding myo-inositol:
- This natural substance has few side effects. It can be safely combined with other medicines if needed. The most common possible manifestations are stomach discomfort and diarrhea when supplements are taken. Therefore, it is recommended to consume a small amount of the nutrient at first, gradually increasing the dosage to reduce the risk of side effects. Since it is a water-soluble substance, excess of it is simply flushed out of the body.
- Myo-inositol is not considered a critical nutrient, which means it is possible to live without it. However, using it in the right amounts will bring significant benefits.
How does myo-inositol contribute to weight loss?
Weight gain and loss are regulated through hormonal activity. Hormones send messages to the brain and tissues to modulate:
- baseline metabolic rate;
- calorie content;
- the amount and location of adipose tissue formation.
In some cases, it is necessary to act on hormones in order to achieve a significant loss of body weight.
So, supplements such as fish oil can help with this, alpha lipoic acid, berberine, even if taken without diet or exercise.
Conditions in which it is worth considering the possibility of using myo-inositol (consultation with a doctor is required):
- Weight loss problems.
- PCOS, high androgen or estrogen levels.
- Infertility due to PCOS or endometriosis.
- Insulin resistance, high blood sugar.
- Type 2 diabetes.
- Non-alcoholic fatty liver disease.
- Established or suspected leptin resistance.
How does myo-inositol affect the process of losing weight?
1. Normalizes leptin, treats leptin resistance
Leptin is a hormone that is synthesized by every cell of adipose tissue and is responsible for the feeling of fullness. It provides feedback to the brain to help the person cope with appetite and calorie burn. Through the bloodstream, leptin reaches the hypothalamus, which is responsible for appetite. The hormone signals satiety, the hypothalamus, in turn, increases metabolism and reduces hunger. As a result, the body begins to consume more calories and feels full.
However, if the volume of excess body weight is constantly increasing, i.e. the amount of adipose tissue that produces the hormone, leptin overflows the bloodstream and the hypothalamus, as a result, the receptor responsible for receiving this information degrades. The connection between the hormone and the hypothalamus is disrupted. A function is activated in the brain - weight gain, the feeling of hunger is constantly present.
This condition is called leptin resistance or leptin resistance. This is a dysregulation of this hormonal system, when weight loss becomes a daunting task if left untreated.
Leptin resistance is common among patients with hypothyroidism and other medical conditions when weight loss problems arise despite a healthy diet and regular exercise.
Myo-inositol is a dietary supplement that treats leptin resistance.
One of the main reasons why the weight of those who lose weight is restored over time is an increase in the level of leptin, which causes hormonal changes. They become the reason for the gain of the previous body weight. Taking myo-inositol blocks the increase in leptin after weight loss.
2. Reduces insulin resistance
Insulin resistance is a condition in which the response of insulin-sensitive tissues to insulin (a pancreatic hormone that controls the amount of glucose in the blood) decreases when its amount in the body is excessive. The cells do not respond properly to the circulating hormone. Therefore, blood glucose is stored as fat rather than used as fuel.
One theory of insulin resistance is related to myo-inositol deficiency. The latter improves the response of the body's cells to the hormone insulin. Many people with insulin resistance are deficient in inositol, such as those with type 2 diabetes or PCOS.
Several studies have shown that taking myo-inositol before meals with a high glucose content reduces the rise in insulin after meals. It is this mechanism - the increase in insulin after a meal - that creates resistance. These scientific studies were carried out with the participation of women, children and adolescents, i.e. myo-inositol is beneficial for almost all age groups.
Why are we interested in insulin? It is considered a hormone that regulates the amount of adipose tissue in the body. High insulin levels trigger the response of fat cells to grow and store energy for later use.
He also participates in the development of disorders such as:
- high estrogen levels;
- low testosterone;
- PCOS;
- heart diseases.
With insulin resistance, if a person is interested in losing weight, a decrease in hormone levels is required.
In summary, myo-inositol can help you lose weight if you have insulin resistance. This condition can be if body weight easily increases after consumption. simple carbohydrates such as bread and pasta made from white flour, sugar and sweets, or have difficulty losing weight even on a low-calorie diet. In all other cases, the nutrient will be ineffective. According to the research, results can be expected for those who are obese, but not for those who want to lose a few pounds.
3. Balances sex hormones
Myo-inositol directly affects the sex hormones: testosterone, estrogen and progesterone:
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How do these hormones affect the weight loss process?
Estrogen affects fat cells. A high amount of the hormone provokes an increase in body weight and the growth of adipose tissue (especially in the chest, buttocks and thighs). It also affects mood and other hormones, such as cortisol.
Many women have excess estrogen due to poor nutrition, insulin resistance, and endocrine problems.
Taking myo-inositol can help correct hormonal imbalances and promote weight loss.
4. Reduces emotional overeating
This nutrient affects nervous system... It raises the level of the neurotransmitter serotonin, which affects mood, well-being and happiness.
By increasing serotonin levels, myo-inositol improves mood and helps with mental health problems - depression, OCD (obsessive-compulsive disorder), anxiety. When a person is feeling well, it is easier for him to control the diet, to stay away from junk food. Thus, myo-inositol will help reduce weight if a person turns to food to improve their mood or if they have an unhealthy food addiction.
The fat breakdown and washout myth
Myo-inositol c promote the transport and emulsification of fats. Inositol is often combined with choline, a vitamin-like substance. While this combination is used to improve brain health, it has other benefits as well.
The body uses inositol and choline to make lecithin. Lecithin is an essential component of cells and is part of cell membranes. In addition, lecithin aids in the transport and emulsification of fats in the body. Therefore, many people take it to control blood cholesterol and triglyceride levels.
Some believe that lecithin promotes weight loss by breaking down fat and flushing it out of the body. There is no evidence to support this. However, it is true that lecithin has not yet been studied for its effects on weight loss. Thanks to this very mechanism, myo-inositol will not help you lose weight.
Myo-inositol for PCOS and infertility
Polycystic ovary syndrome (PCOS) can be thought of as a combination of 2 main problems:
- Hormone imbalance: high estrogen and testosterone (androgen) levels, low progesterone, infertility, insulin resistance.
- Metabolic dysfunction: high cholesterol, weight gain, high blood pressure, abdominal obesity, impaired glucose metabolism.
Myo-inositol has:
- hormonal action: reduces insulin, improves estrogen levels, normalizes androgens;
- metabolic action: reduces blood sugar, cholesterol and blood pressure.
The advantage of myo-inositol is the ability to combine it with existing treatment methods, for example, with metformin (prescribed for patients with type 2 diabetes mellitus in case of ineffective diet therapy). Compared to this drug, the nutrient is better tolerated and does not cause problems with the glycemic index.
In addition, myo-inositol treatment may be an option (for safety reasons) for patients seeking to become pregnant or improve fertility.
Myo-inositol is one of the few treatments for PCOS that treats not only the symptoms of the disease, but also the underlying cause without serious unwanted side effects.
Research has shown that myo-inositol is as effective as metformin for improving fertility, plus it has a safer profile.
How to take myo-inositol?
According to the research results, weight loss was observed in participants with the following diagnoses:
- PCOS;
- metabolic syndrome;
- type 2 diabetes.
Doses of inositol were ranged from 2 to 4 grams per day. At the same time, higher doses brought better results - improved markers of metabolic syndrome and increased the amount of weight lost.
If a supplement with inositol is used, more volume is needed to obtain the correct amount of myo-inositol, as its most common form.
- Improves insulin resistance, blood sugar.
- Promotes weight loss by normalizing hormone levels.
- Reduces the amount of leptin in the body and eliminates leptin resistance.
- Well tolerated, has few side effects, can be used with other drugs and treatments.
How to use?
The best way to take myo-inositol on an empty stomach. This ensures maximum absorption, so you can get the most benefit from the supplement.
Some specialists, for example, Dr. Westin Childs provides the following guidelines:
- Take up to 2,000 mg twice a day (for a total of 4,000 mg per day). In 1 tsp. maybe 2,400 mg, so 2 tsp a day.
- Continue treatment for 3 to 6 months (or until improvement is evident).
- For best results, can be combined with other dietary supplements designed to lower leptin and insulin levels.
- It is possible to increase the bioavailability of inositol by injection.
Inositol Injection with B12 + MIC
This is the second and more efficient way to get inositol. MIC stands for methionine, inositol and choline. These nutrients complements inositol and are considered if weight loss is the primary goal.
In conclusion, it is worth noting again that myo-inositol is a dietary supplement, it has not received FDA approval as a drug for the prevention or treatment of any condition. Research on the effects of myo-inositol on weight loss is limited and large-scale trials are required.
Based on materials:
- https://www.restartmed.com/myoinositol/
- https://www.1stopwellbeing.com/supplements-and-herbs/inositol/weight-loss
- https://www.youtube.com/watch?time_continue=336&v=r-UQ8hHromo
- https://nootriment.com/inositol-for-weight-loss/
- https://ru.wikipedia.org/wiki/