How to take ascorbic acid 50 mg. Ascorbic acid dragee: instructions for use

Instructions for use

Attention! The information is provided for informational purposes only. This instruction should not be used as a guide to self-medication. The need for prescription, methods and doses of the drug are determined exclusively by the attending physician.

general characteristics

Composition of the medicinal product:

active substance: ascorbic acid;

1 tablet contains ascorbic acid, in terms of 100% substance 50 mg;

Excipients: sugar, starch syrup, talc, yellow wax, orange flavor, light mineral oil, quinoline yellow dye (E 104).

Dosage form. Dragee.

Dragee yellow color... It should have a spherical shape in appearance. The surface of the dragee should be uniform in color.

Pharmacotherapeutic group

Ascorbic acid preparations ( vitamin (Vitamins- organic substances formed in the body with the help of intestinal microflora or supplied with food, usually vegetable. Necessary for normal metabolism and vital functions) WITH). Vitamin C... ATC code A11G A01.

Pharmacological properties

Ascorbic acid is involved in redox reactions, metabolism (Metabolism- the totality of all types of transformations of substances and energy in the body, ensuring its development, vital activity and self-reproduction, as well as its connection with the environment and adaptation to changes in external conditions) carbohydrates (Carbohydrates- one of the main components of cells and tissues of living organisms. Provide all living cells with energy (glucose and its storage forms - starch, glycogen), participate in the body's defense reactions (immunity). From food products the richest in carbohydrates are vegetables, fruits, flour products. Used as medicines (heparin, cardiac glycosides, some antibiotics). The increased content of certain carbohydrates in the blood and urine is an important diagnostic sign of certain diseases (diabetes mellitus). The daily human need for carbohydrates is 400-450 g), tyrosine, gland (Glands- organs that produce and secrete specific substances that are involved in various physiological functions and biochemical processes of the body. The endocrine glands secrete their waste products - hormones directly into the blood or lymph. External secretion glands - on the surface of the body, mucous membranes or into the external environment (sweat, salivary, mammary glands)), the conversion of folic acid to folinic acid, blood coagulation, in the formation of steroid hormones (Hormones- biologically active substances produced in the body by specialized cells or organs (endocrine glands) and having a targeted effect on the activity of other organs and tissues), collagen (Collagen- fibrillar protein, which forms the basis of animal connective tissue (tendon, bone, cartilage) and provides its strength) and procollagen, tissue regeneration, regulation of permeability capillaries (Capillaries- the smallest vessels that penetrate organs and tissues. Connect arterioles with venules (smallest veins) and close the circle of blood circulation), synthesis lipids (Lipids- an extensive group of natural organic compounds, including fats and fat-like substances. Contained in all living cells. They form the body's energy reserve, participate in the transmission of a nerve impulse, in the creation of water-repellent and thermal insulating covers, etc.) and proteins (Squirrels- natural high molecular weight organic compounds. Proteins play an extremely important role: they are the basis of the life process, participate in the construction of cells and tissues, are biocatalysts (enzymes), hormones, respiratory pigments (hemoglobins), protective substances (immunoglobulins), etc.), processes of cellular respiration.

Vitamin C helps to increase the body's resistance to infections and adverse environmental influences.

Ascorbic acid has antidote properties. Promotes absorption (Absorption- the process by which the drug from the injection site enters the blood vessels) iron in the intestine and takes part in the synthesis of hemoglobin.

After oral (Orally- the route of administration of the drug through the mouth (per os)) reception ascorbic acid is rapidly absorbed in the small intestine, its maximum concentration in plasma (Plasma- the liquid part of the blood, which contains the formed elements (erythrocytes, leukocytes, platelets). According to changes in the composition of blood plasma, various diseases are diagnosed (rheumatism, diabetes mellitus, etc.). Medicines are prepared from blood plasma) blood is determined after 4-7 hours. From the blood plasma, it penetrates primarily into the blood elements ( leukocytes (Leukocytes- colorless human and animal blood cells that absorb bacteria and dead cells and produce antibodies. Includes granulocytes, lymphocytes and monocytes), platelets (Platelets- blood cells involved in the process of blood clotting. With a decrease in their number - thrombocytopenia - there is a tendency to bleeding), erythrocytes (Erythrocytes- red blood cells containing hemoglobin. They carry oxygen from the lungs to the tissues and carbon dioxide from the tissues to the respiratory organs. Formed in the red bone marrow. 1 mm3 of a healthy person's blood contains 4.5-5.0 million erythrocytes)), then into all fabrics. Plasma protein binding is about 25%.

Ascorbic acid is reversibly oxidized to form dihydroascorbic acid, part of it is metabolized to form ascorbate-2-sulfate and oxalic acid (Oxalic acid- a widespread dicarboxylic acid that enters the body with food, as well as formed as the end product of oxidative deamination of glycine; excreted in the urine in the form of calcium oxalate), which is excreted in the urine. Excess ascorbic acid is excreted in the urine unchanged.

Indications for use

Prevention and treatment of vitamin C deficiency. Providing an increased need for vitamin C in the body during growth, pregnancy or lactation; with increased physical and mental stress, with infectious diseases and intoxications (Intoxication- poisoning of the body with toxic substances), hemorrhagic diathesis (Hemorrhagic diathesis- hereditary or acquired pathology, characterized by increased bleeding), in a complex therapy (Therapy- 1. The field of medicine, which studies internal medicine, is one of the most ancient and basic medical specialties. 2. Part of a word or phrase used to indicate the type of treatment (oxygen therapy \; hemotherapy - treatment with blood preparations)) bleeding (nasal, pulmonary, uterine); with radiation sickness, Addison's disease, overdose anticoagulants (Anticoagulants- medicinal substances that reduce blood clotting), for soft tissue injuries and infected wounds that heal slowly, bone fractures.

Contraindications

Hypersensitivity to drug components, thrombosis, tendency to thrombosis, thrombophlebitis (Thrombophlebitis- venous disease characterized by inflammation of the venous wall and thrombosis. The onset of thrombophlebitis is preceded by inflammation of the vein - phlebitis and periphlebitis), diabetes mellitus, severe kidney disease, urolithiasis disease (Urolithiasis disease- formation of kidney stones)(when used over 1 g per day), fructose intolerance, children under 4 years of age.

Method of administration and dosage

The drug is taken orally, after meals.

For prophylaxis, adults and children from 14 years old should take 1-2 tablets (50-100 mg) per day, children from 4 to 14 years old - 1 tablet (50 mg) per day.

Therapeutic doses for children from 14 years old and adults are 1-2 pills (50-100 mg) 3-5 times a day, for children from 4 to 7 years old - 1-2 pills (50-100 mg) 2-3 times a day, at the age of 7-10 years - 2 tablets (100 mg) 2-3 times a day, at the age of 10-14 years - 2-3 tablets (100-150 mg) 2-3 times a day.

Pregnant women and women after childbirth and with a low level of vitamin C in breast milk should take 6 pills (300 mg) per day for 10-15 days, then for prevention, 2 pills (100 mg) per day for the entire period of breastfeeding.

The duration of treatment depends on the nature and course of the disease and is determined by the doctor individually.

Application features

Appropriate safety precautions for use.

When taking large doses and long-term use of the drug, it is necessary to monitor renal function and blood pressure, as well as the function of the pancreas. The drug should be used with caution in patients with a history of kidney disease.

In case of urolithiasis, the daily dose of ascorbic acid should not exceed 1 g.

You should not prescribe high doses of the drug to patients with increased blood clotting.

Since ascorbic acid increases the absorption of iron, its use in high doses can be dangerous for patients with hemochromatosis, thalassemia (Thalassemia- anemia due to increased hemolysis, which occurs due to a defect in the structure of hemoglobin), polycythemia, leukemia and sideroblastic anemic (Anemia- a group of diseases characterized by a decrease in erythrocytes or hemoglobin in the blood)... Patients with a high iron content in the body should use the drug in minimal doses.

The absorption of ascorbic acid can be impaired in case of intestinal dyskinesia, enteritis and achilia.

It is used with caution to treat patients with glucose-6-phosphate dehydrogenase deficiency.

Ascorbic acid as a reducing agent can affect the results of various laboratory tests, for example, when determining blood levels glucose (Glucose- grape sugar, a carbohydrate from the group of monosaccharides. One of the key metabolic products that provides living cells with energy), bilirubin, activity transaminase (transaminases- enzymes of the class of transferases, the reactions catalyzed by them carry out a connection between protein and carbohydrate metabolism), lactate dehydrogenase, etc.

Application during pregnancy or lactation.

The drug can be used during pregnancy or lactation in accordance with the dosage recommendations and the doctor's prescription. The recommended doses should be carefully followed and not exceeded.

Children. The drug is used in children aged 4 years and older.

The ability to influence the rate of reactions when driving or operating other mechanisms.

The drug does not affect therapeutic doses (Therapeutic dose- dose within therapeutic latitude) on the reaction rate when driving or working with other mechanisms.

Side effect

From the digestive tract: when used in excess of 1 g per day - irritation of the mucous membrane of the digestive tract, heartburn, nausea, vomiting, diarrhea;

from the urinary system: damage to the glomerular apparatus of the kidneys, crystalluria (Crystalluria- the presence of crystals in the urine), the formation of urate, cystine and / or oxalate calculi in the kidneys and urinary tract;

allergic reactions: skin rash, angioedema (Quincke's edema- (angioedema), an acute limited paroxysmal edema of tissues - the body's reaction to an allergen. Externally, Quincke's edema is manifested by sharply limited swelling of tissues (mainly lips, eyelids, cheeks), sometimes skin rashes at the site of edema, usually without itching and pain), hives (Hives- a disease characterized by the formation of limited or widespread itchy blisters on the skin and mucous membranes); sometimes - anaphylactic shock (Anaphylactic shock- a symptom complex of acutely arising general severe manifestations of immediate allergic reactions, mainly characterized by initial excitement and subsequent suppression of the function of the central nervous system, bronchospasm, severe arterial hypotension) in the presence of sensitization;

from the endocrine system: with prolonged use in high doses - damage to the insular apparatus of the pancreas (hyperglycemia, glucosuria);

from the nervous system: headache, feeling of heat, increased excitability, sleep disturbance;

on the part of the cardiovascular system:arterial hypertension (Arterial hypertension- a disease characterized by an increase in blood pressure of more than 140/90 mm Hg. Art.), dystrophy (Dystrophy- pathological changes in cells of a regressive nature with impairment or loss of their functions) myocardium;

on the part of the blood and lymphatic system: thrombocytosis, erythrocytopenia, thrombus formation, neutrophilic leukocytosis (Leukocytosis- an increase in the number of leukocytes per unit of blood volume. It can be physiological and pathological - for many infectious, inflammatory and other diseases), hyperprothrombinemia; in patients with deficiency of glucose-6-phosphate dehydrogenase of blood cells, it can cause hemolysis of erythrocytes;

from the side of metabolism: violation of the metabolism of zinc, copper.

Interaction with other medicinal products

The drug reduces toxicity (Toxicity- the ability of some chemical compounds and substances of biological nature to have a harmful effect on the human body, animals and plants) sulfonylamide drugs, reduces the effect of heparin and indirect anticoagulants, promotes the absorption of iron, increases the absorption of penicillin and tetracycline, enhances the side effect of salicylates (risk of crystalluria).

The absorption of ascorbic acid is reduced with the simultaneous use of oral contraceptives (Contraceptives- prevention of pregnancy with contraception), consumption of fruit or vegetable juices, alkaline drinks.

The combined intake of vitamin C and deferoxamine increases the tissue toxicity of iron, especially in the heart muscle, which can lead to decompensation of the circulatory system. It can be taken 2 hours after injections (Injection- injection, subcutaneous, intramuscular, intravenous, etc. introduction into the tissues (vessels) of the body of small amounts of solutions (mainly drugs)) deferoxamine.

Long-term use of high doses by persons treated with disulfiramine inhibits the disulfiram-alcohol reaction.

Large doses of the drug reduce the effectiveness of tricyclic antidepressants (Antidepressants- funds that improve mood, relieve anxiety and tension, increase mental activity. Used to treat depression), antipsychotics (Antipsychotics- medicinal substances that have a depressing effect on the functions of the central nervous system and are able to eliminate or weaken some symptoms of psychosis (delirium, hallucinations))- phenothiazine derivatives, tubular reabsorption of amphetamine, increase the excretion of mexiletine by the kidneys. Ascorbic acid increases overall clearance (Clearance(purification, purification) - a pharmacokinetic parameter reflecting the rate of purification of blood plasma from a drug and denoted by the symbol C1) ethanol. Quinoline series drugs, calcium chloride, salicylates, corticosteroids (Corticosteroids- hormones produced by the adrenal cortex. Regulate mineral metabolism and metabolism of carbohydrates, proteins and fats. They are used in medicine for their deficiency in the body, as anti-inflammatory and antiallergic agents) with prolonged use, they reduce the reserves of ascorbic acid in the body.

Overdose

Symptoms: epigastric pain, nausea, vomiting, flatulence (Flatulence- accumulation of gas in the digestive tract with bloating, rumbling, belching, cramping pains), diarrhea (Diarrhea- increased excretion of liquid feces associated with the accelerated passage of intestinal contents due to increased peristalsis, impaired absorption of water in the large intestine and the release of a significant amount of inflammatory secretion by the intestinal wall), itching (Itching- a modified feeling of pain caused by irritation of the nerve endings of pain receptors) and skin rash, increased excitability of the nervous system.

With prolonged use in high doses, it is possible to suppress the insular apparatus of the pancreas, develop cystitis, and accelerate the formation of calculi (urates, oxalates).

Treatment: gastric lavage, sorbents, symptomatic treatment.

General product information

Best before date... 1 year 6 months.

Storage conditions. Store in its original packaging at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Package. 10 dragees in blisters. 10 dragees in a blister; 3 blisters in a pack.

50 dragees in blisters.

160 dragees in containers (jars). 160 pills in a container (jar); 1 container (jar) in a pack.

Manufacturer.Public Joint Stock Company "Kiev Vitamin Plant".

Location. 04073, Ukraine, Kiev, st. Kopylovskaya, 38.

Site. www.vitamin.com.ua

Preparations with a similar active ingredient

- "Health"
Vitamin C - "Arterium"
Vitamin C - "Health"
Vitamin C 500 - "Kiev Vitamin Plant"
Ascorbic acid - "Arterium"

This material is presented in free form based on the official instructions for the medical use of the drug.

Formula: C6H8O6, chemical name: L-Ascorbic acid.
Pharmacological group: metabolites / vitamins and vitamin-like agents.
Pharmachologic effect: metabolic, replenishing vitamin C deficiency, antioxidant, regulating the processes of recovery and oxidation.

Pharmacological properties

Ascorbic acid has very pronounced antioxidant properties. It regulates the transfer of hydrogen protons in almost all biochemical processes, improves the use of glucose in the tricarboxylic acid cycle, participates in tissue regeneration and the synthesis of tetrahydrofolic acid, collagen, steroid hormones, carnitine, procollagen, and serotonin hydroxylation processes. Maintains normal capillary permeability (inhibiting hyaluronidase) and colloidal state in the intercellular substance. It activates proteolytic enzymes, takes part in the metabolism of pigments, aromatic amino acids and cholesterol, helps in the accumulation of glycogen in the liver. By activating respiratory enzymes in the liver, it increases its protein-forming and detoxifying functions, increases the synthesis of prothrombin. Improves the processes of bile secretion, restores the secretion of enzymes in the pancreas and hormones in thyroid gland ... Stimulates immunological reactions (promoting phagocytosis, activates the synthesis of the C3 component of complement, antibodies, interferon), increases the body's resistance to infections. It has anti-inflammatory and anti-allergic effects by inhibiting the production and accelerating the destruction of histamine, inhibiting the synthesis of prostaglandins and other mediators of allergy and inflammation. Reduces the body's need for vitamins such as E, B1, A, B2, pantothenic and folic acids. With a lack of ascorbic acid, hypovitaminosis develops, and in severe cases, vitamin deficiency (scurvy, scurvy). Absorption of ascorbic acid occurs in the small intestine (mainly in the duodenum, partially absorbed in the ileum). When the dose is increased to 200 mg, up to 70% of the drug enters the bloodstream; a further increase in the dose leads to a decrease in absorption to 50–20%. Diseases of the stomach and intestines (ulcers, constipation, diarrhea), giardiasis, helminthic invasion, eating fresh juices from vegetables and fruits, alkaline drinks - reduce the absorption of ascorbic acid. 4 hours after ingestion, the maximum concentration in the blood will be reached. It binds to plasma proteins by about 25%. Ascorbic acid easily gets into platelets, leukocytes, and then into all tissues; the highest concentrations of ascorbic acid are found in the glandular tissue. It accumulates in the pituitary gland, its posterior lobe, ocular epithelium, adrenal cortex, ovaries, seminal glands (in the interstitial cells), liver, spleen, brain, pancreas, kidneys, lungs, heart, intestinal wall, thyroid gland, muscles. Penetrates the placental barrier. The metabolic processes of ascorbic acid occur mainly in the liver, from the beginning it turns into deoxyascorbic acid and then into diketogulonic and oxaloacetic acids. Unchanged and in the form of metabolites are excreted in urine, breast milk, sweat, feces. It is also excreted during hemodialysis. At high doses, with a plasma concentration of more than 1.4 mg / dL, excretion rapidly increases, and such a high excretion may remain even when the administration is discontinued. The use of ethyl alcohol and smoking accelerate the destruction of ascorbic acid with the formation of inactive metabolites, while its reserves in the body are sharply reduced. When used as a vaginal tablet, vitamin C lowers vaginal pH by inhibiting bacterial growth and helping to maintain and restore normal pH and vaginal microflora (Lactobacillus gasseri, Lactobacillus acidophilus). That is, with a decrease in the pH of the vagina in a few days, there is a pronounced decrease in the growth of anaerobic bacteria and the restoration of normal microflora.

Indications

Avitaminosis and hypovitaminosis C (treatment and prevention); capillarotoxicosis; hemorrhagic diathesis; hemorrhagic stroke; idiopathic methemoglobinemia; infectious diseases; bleeding (including nose, uterine, pulmonary); intoxication (including chronic intoxication with iron preparations); infectious and alcoholic delirium; radiation sickness; complications after transfusions of blood and its components; liver disease (chronic hepatitis and cirrhosis, Botkin's disease), diseases of the gastrointestinal tract (peptic ulcer, especially with bleeding, achilia, colitis, enteritis); cholecystitis; helminthiasis; adrenal insufficiency (Addison's disease); poorly healing ulcers, wounds, bone fractures, burns; dystrophy; mental and physical overload; recovery period after illness; pregnancy (especially with multiple fetuses, against the background of drug or nicotine addiction); lactation; psoriasis; melasma; hemosiderosis; chronic common dermatoses; erythroderma; in laboratory practice, it is used for labeling erythrocytes (together with sodium chromate); vaginal tablets for chronic or recurrent vaginitis, which are caused by anaerobic flora, as well as for the normalization of altered vaginal microflora.

Dosing and administration of ascorbic acid

Ascorbic acid is used orally, intramuscularly, intravenously, intravaginally. Inside, take after meals (preferably 2 hours before and after, do not eat fresh fruits and vegetables and their juices, also do not drink alkaline drinks), washed down with a small amount of water. For prevention (in winter and spring, with malnutrition): adults - 50-100 mg / day (children - 25-75 mg / day), during pregnancy and breastfeeding - 300 mg / day for 10-15 days, then - 100 mg / day For treatment: adults - 50-100 mg 3-5 times a day (children - 50-100 mg 2-3 times a day). Intravenous and intramuscularly administered 5-10% solutions of 1-5 ml, in case of poisoning - up to 3 g (60 ml). The duration of therapy depends on the disease itself and its course. 1 vaginal tablet is injected intravaginally before bedtime for 6 days, the course can be repeated.
If you skip the next intake of ascorbic acid, you need to take it as you remember, the next intake should be done after the time specified by the doctor.
When administered intravenously, rapid administration should be avoided. Long-term treatment requires control over blood pressure, kidney function, glucose levels (especially if large doses are used). It is very careful to prescribe high doses of ascorbic acid to patients who suffer from diabetes mellitus, urolithiasis, cancer, are prone to thrombosis and receive anticoagulants, are on a salt-free diet. Due to the fact that ascorbic acid is a reducing agent, it can distort the results of laboratory tests (blood levels of bilirubin, glucose, LDH activity, transaminases, glucose in urine, up to false negative results in fecal occult blood tests). Ascorbic acid does not reduce the growth of fungal flora in the vagina when used as a vaginal tablet. Such manifestations as itching and burning can also occur with a concomitant fungal infection, therefore, with these symptoms, it is necessary to exclude the presence of a fungal infection. For menstrual or inter-cycle bleeding, interruptions in the use of vaginal tablets are not necessary.

Contraindications and restrictions for use

Hypersensitivity, tendency to thrombosis, thrombophlebitis, for vaginal tablets - vulvovaginal candidiasis. Limit intake of ascorbic acid when diabetes mellitus, hemochromatosis, glucose-6-phosphate dehydrogenase deficiency, thalassemia, sideroblastic anemia, oxalosis, hyperoxaluria, urolithiasis.

Application during pregnancy and lactation

In the 2nd and 3rd trimesters of pregnancy, the daily minimum requirement for vitamin C is approximately 60 mg. It must be remembered that the fetus may become accustomed to the high doses of ascorbic acid that a woman uses during pregnancy, and then the newborn may develop withdrawal symptoms. Therefore, during pregnancy, you should not use ascorbic acid in high doses, unless the predicted benefit outweighs the potential risk to the fetus. There is evidence that therapy with high doses of ascorbic acid during pregnancy is associated with the possibility of developing scurvy in newborns, and with intravenous use in high doses, there is a threat of termination of pregnancy due to estrogenesis (these effects are non-teratogenic). The daily minimum requirement during lactation is 80 mg. A mother's diet that contains adequate levels of ascorbic acid will be sufficient to prevent a deficiency in an infant. Theoretically, there is a danger to the child when using high doses of ascorbic acid by the mother (it is recommended that a nursing mother not exceed daily requirement in vitamin C). Animal studies on the effect of injectable forms of ascorbic acid on reproductive function have not been conducted. It is also not known whether ascorbic acid, when injected into pregnant women, can have embryotoxic effects or impair fertility. Injectable forms should be prescribed during pregnancy only in extreme cases.

Side effects of ascorbic acid

Circulatory system and blood: hyperprothrombinemia, thrombocytosis, erythropenia, neutrophilic leukocytosis; nervous system: with rapid intravenous administration: dizziness, weakness; digestive system: when used internally - irritation of the mucous membrane of the stomach and intestines (diarrhea, nausea, vomiting), diarrhea (if taken more than 1 g / day), damage to the tooth enamel (with frequent use of chewable tablets, as well as with the absorption of oral forms); allergic reactions: skin flushing, skin rash; metabolism: metabolic disorders, increased formation of corticosteroids, inhibition of glycogen synthesis, water and sodium retention, hypokalemia; genitourinary system: increased urine output, formation of oxalate urinary stones (with prolonged intake of more than 1 g / day), damage to the glomerular apparatus of the kidneys; others: soreness at the injection sites, for vaginal tablets - local reactions in the form of itching or burning in the vagina, increased mucous discharge, swelling and redness of the vulva.

Interaction of ascorbic acid with other substances

Ascorbic acid increases the level of salicylates in the blood (which increases the possibility of crystalluria), tetracyclines and benzylpenicillin, ethinyl estradiol, and decreases the concentration of oral contraceptives. Oral contraceptives, acetylsalicylic acid, alkaline drinks, fresh juices reduce the absorption and assimilation of ascorbic acid. Ascorbic acid enhances the effect of norepinephrine and reduces the anticoagulant effects of heparin and coumarin derivatives. When taken orally with iron preparations, it increases their absorption. When used together with deferoxamine, it is possible to increase the tissue toxicity of iron, including the toxic effect on the heart, up to the development of heart failure. Ascorbic acid increases the total clearance of ethyl alcohol. It may also affect the effectiveness of disulfiram during the treatment of chronic alcoholism. Drugs such as calcium chloride, salicylates, corticosteroids, quinoline series agents, with prolonged use, deplete vitamin C reserves in the body. When mixed in one syringe, a solution of ascorbic acid enters into chemical interaction with many drugs.

Overdose

With prolonged use of large doses (more than 1 g), signs of overdose may appear: headache, insomnia, increased excitability, nausea, vomiting, hyperacid gastritis, diarrhea, ulceration of the gastric and intestinal mucosa, inhibition of the insular apparatus of the pancreas (glucosuria, hyperglycemia), hyperoxaluria, damage to the renal glomerular apparatus, nephrolithiasis, moderate pollakiuria (when taking a dose of more than 600 mg / day), hypercoagulation, arterial hypertension, the development of microangiopathies, with intravenous administration of large doses - hemolysis of erythrocytes, the threat of termination of pregnancy. Need hospitalization, dose reduction or withdrawal of the drug, symptomatic therapy, possibly hemodialysis.

Trade names of drugs with active ingredient ascorbic acid

Askovit®
Additive Vitamin C
Vitamin C
Ascorbic acid (vitamin C)
Ascorbic acid with sugar
Ascorbic acid bufus
Ascorbic Acid-Vial
Ascorbic acid-UBF
Ascorbic acid-Rusfar

Ascorbic acid injection 5%
Ascorbic acid injection 10%
Ascorbic acid dragee 0.05 g
Ascorbic acid tablets 0.05 g
Ascorbic acid tablets 0.025 g
Vitamin C
Vaginorm-S
VITAMIN C PLUS Kid's formula Pharmamed®
Vitamin C 500

Vitamin C-Injectopas
Multi-tabs® with Vitamin C
Ascorbic acid (vitamin C)
Rostvit
Plivit C
Setebe 500
Celascon® effect Vitamin C
Celascon® Vitamin C
Celascon® Effectscens
Tsevikap

Water-soluble vitamin found in foods vegetable origin, which is important for the life of the body.

ATX code: A11G A01. A11G B10. Vitamin C group.

Daily requirement for ascorbic acid

The daily human need for ascorbic acid is usually no more than 50-100 mg, but it increases significantly with severe physical activity, exposure to cold or high temperatures, with infectious diseases, neuropsychic stress, pain syndrome, pregnancy.

With a lack of ascorbic acid and vitamin P in food, scurvy develops.

Indications for use

Avitaminosis C (scurvy) and hypovitaminosis C - prevention and treatment.
Bleeding (nasal, pulmonary, hepatic, uterine, etc.). Hemorrhagic stroke. Hemorrhagic diathesis. Capillarotoxicosis. Vasculitis (in combination with a routine).
Intoxication. Long-term use of antibiotics, salicylates, corticosteroids, anti-tuberculosis drugs-derivatives of GINK, antimalarial drugs.
Infectious diseases.
Alcoholic and infectious delirium.
Post-transfusion complications.
Diseases of the gastrointestinal tract (achilia; peptic ulcer of the stomach and duodenum, especially after bleeding; enteritis, colitis, enterocolitis, helminthiasis).
Liver diseases (Botkin's disease, chronic hepatitis and liver cirrhosis). Cholecystitis.
Adrenal insufficiency (Addison's disease).
Acute radiation sickness.
Hemosiderosis, hemoderma, melasma, erythroderma, psoriasis, eczema, neurodermatitis, pemphigus, Dühring's dermatitis, strofulus, urticaria, skin porphyria, infectious skin diseases.
Sluggish healing wounds, ulcers, bone fractures, dystrophy.
Pregnancy and lactation periods. Nephropathy of pregnant women.

As an antioxidant, ascorbic acid is used in atherosclerosis, bronchial asthma, diffuse connective tissue diseases (rheumatoid arthritis, scleroderma, systemic lupus erythematosus).

Application rules

Ascorbic acid is administered orally, injected intramuscularly and intravenously.

For treatment:

Adults are prescribed 0.05-0.2 g of ascorbic acid for oral administration 3-5 times a day after meals. Intramuscularly or intravenously, adults are injected 1-5 ml of 5% sodium ascorbate solution 1-3 times a day.
For the treatment of deficiency conditions in children, 0.03–0.05 g of ascorbic acid is prescribed (0.6–1 ml of a 5% solution is administered).

The duration of the course of treatment is individual, depending on the type of disease, the nature of the pathological process and the effectiveness of therapy (monotherapy or complex treatment).

For prevention:

For adults, ascorbic acid is prescribed for oral administration at 0.05–0.1 g per day (for adults).
Children are prescribed orally for prophylaxis at 0.05-0.1 g of ascorbic acid 1-2 times a day, parenterally - 1-2 ml of a 5% solution per day for 2-3 weeks.

Higher doses of ascorbic acid

For adults: single dose - no more than 0.2 g, daily dose - no more than 0.5 g.
Daily doses of ascorbic acid for children: up to 6 months - 30 mg, from 6 to 12 months - 35 mg, from 1 to 3 years old - 40 mg, from 4 to 10 years old - 45 mg, from 11 to 14 years old - 50 mg.

Side effects

With prolonged use of high doses of ascorbic acid, arterial hypertension, damage to the glomerular apparatus of the kidneys, metabolic disorders, inhibition of the function of Langerhans cells of the insular apparatus of the pancreas (hyperglycemia, glucosuria), inhibition of glycogen synthesis, decrease in capillary permeability and deterioration of tissue trophism, development of microangiopathies , increased blood clotting, thrombocytosis, hyperprothrombinemia, thrombosis, erythrocytopenia, neutrophilic leukocytosis (neutrophillosis), myocardial dystrophy, allergic reactions (including anaphylactic shock); the formation of urinary stones (oxalates and urates) is possible; violation of the metabolism of zinc, copper; increased excitability of the central nervous system, sleep disturbances.

With an overdose of ascorbic acid, an increase occurs side effects, symptomatic treatment.

Contraindications

Individual intolerance to ascorbic acid. Intravenous administration of ascorbic acid is contraindicated in severe diabetes mellitus, increased blood clotting and a tendency to thrombosis, thrombophlebitis.

Pregnancy and lactation

Ascorbic acid is used during pregnancy and lactation.

Interaction with other medicinal products

The use of ascorbic acid increases the concentration in the blood of salicylates, ethinylestradiol, benzylpenicillin and tetracyclines, reduces the concentration of oral contraceptives. Reduces the coagulation effect of coumarin derivatives. Improves intestinal absorption of iron preparations. Increases the total clearance of ethyl alcohol. Preparations of the quinoline series, calcium chloride, salicylates, corticosteroids, with prolonged use, reduce the reserves of vitamin C in the body.

With an excessive introduction of vitamin A, the supply of the body with ascorbic acid decreases.

Ascorbic acid is incompatible:
in solutions - with oxidants and alkalis (oxidation and inactivation of the drug occurs), sodium salts of barbiturates and sulfonamides (due to the formation and precipitation of acidic forms of barbiturates and sulfonamides);
in mixtures - with temisal (theobromine base is precipitated) and sodium thiosulfate (thiosulfate decomposes with the release of oxygen and sulfur);
in powders - with sodium bicarbonate and many substances with an alkaline reaction (dampness and yellowing of preparations).

special instructions

When using ascorbic acid in large doses, it is necessary to control the function of the kidneys and blood pressure, as well as the level of glucose and coagulogram.

Patients with hypoacid or anacid conditions are prescribed a solution of hydrochloric acid with pepsin before taking ascorbic acid to prevent the destruction of vitamin C.

Ascorbic acid, as a reducing agent, can distort the results of various laboratory tests (blood glucose, bilirubin, transaminases, lactate dehydrogenase (LDH).

Composition and form of release

Ascorbic acid recipes

Ascorbic acid tablets (Tabulettae Acidi ascorbinici) 0.1 g, in packs of 30 tablets.
Tablets of 0.025 g, in blisters of 10 tablets, in polymer containers of 50 or 100 tablets. 1 tablet contains: ascorbic acid - 250 mg; excipients: sugar, potato or corn starch, povidone 25, orange flavor, magnesium stearate.
Tablets of 0.5 g, in blisters of 10 tablets, in polymer containers of 50 or 100 tablets. 1 tablet contains: ascorbic acid - 500 mg; excipients: granulated sugar, potato or corn starch, povidone 25, orange flavor, magnesium stearate.
Drops of 0.025 g in blisters of 10, 25, 30 pills, cans of 200 pills. 1 tablet contains 25 mg of ascorbic acid.
Dragees of 0.05 g, in blisters of 50 dragees, glass jars and plastic containers of 50 or 160 dragees. 1 tablet contains: ascorbic acid - 50 mg; auxiliary substances: sugar, starch syrup, talc, beeswax, vaseline oil, quinoline yellow dye (E104), food aromatic essence.
Tablets for chewing with orange flavor, 0.18 g (0.5 g), 10 or 20 (10 × 2) in blisters, 30 or 60 tablets in plastic containers, 50 tablets in glass jars. 1 tablet contains: ascorbic acid - 180 mg (500 mg); excipients: ulucose, potato or corn starch, aspartame, stearic acid or calcium stearate, gelatin, orange flavor, food coloring E110 (sunset yellow or FD & Yellow No. 6 Lake).
Tablets for food fortification, containing 0.5 g or 2.5 g of ascorbic acid, in packs of 10 tablets.
5% solution: clear or slightly yellowish liquid in ampoules of 1 ml, 2 ml or 5 ml, in packs of 10 ampoules of the composition (per 1 ml): ascorbic acid - 50 mg; excipients: sodium bicarbonate, sodium metabisulfite anhydrous (sodium pyrosulfite), Trilon B, water for injection.
10% solution of ascorbic acid in 2 ml ampoules, in packs of 10 ampoules. 1 ml of solution contains: ascorbic acid - 100 mg; excipients: sodium bicarbonate, sodium metabisulfite, sodium edetate (Trilon B), water for injection.
Powder (0.1 g).

It is an ingredient in various multivitamin complexes and is used to obtain a number of combined drugs (, etc.).

Shelf life and storage conditions

Store at a temperature of 15-25 ° C in a dry, protected from light, out of reach of children. Available without a prescription.

Shelf life of ascorbic acid: ampoules and pills - 1.5 years, tablets - 3 years.

Properties

(Acidum ascorbinicum) - γ-lactone-2,3-dehydro-L-gulonic acid; [(R) -5 - [(S) -1,2-dihydroxyethyl] -3,4-dihydroxy-5H-furan-2-one] is a white powder with a sour taste.

Analogs

Ascorbin. Ascorbit. Ascorvitis. Vitamin C. Vitascorbol. Vitsin. Kantan. Kanthaksin. Lariscorbine. Redoxon. Skorbumin. Scorbutamine. Cebion. Tsevamin. Cevex. Tsevimin. Cevita. Cecon. Tselin. Tsenetone.

Instructions

Ascorbic acid is indicated for hypo- and auto-deficiency C. In particular, the agent is recommended to be used at moments of high demand for this element - during pregnancy, breastfeeding, children - during the period of growth. Also, ascorbin is indicated for the recovery of the body after illness and during epidemics. The remedy is prescribed for vaginitis with anaerobic flora. Ascorbin can be taken orally (tablets, dragees, granules, powder), in the form of injections, and also vaginally.

For the prevention of diseases, ascorbic acid is taken in the winter and spring periods, when the body does not receive enough vitamins, as well as in case of malnutrition. The daily prophylactic dose for contains 50-100 mg, for children - 25-75 mg of the drug. When treating vitamin deficiency, it is 50-100 mg of ascorbic acid, while adults should drink the drug 3-5 times a day, children 2-3 times a day. You need to take vitamin C within 2 weeks. Ascorbic acid granulate or powder is used for making drinks. To do this, 1 g of the product (1/3 teaspoon) should be dissolved in 1 liter of water. Based on the dosage, adults can drink up to 500 ml, and children - up to 300 ml per day.

Pregnant and lactating women should use ascorbic acid under the supervision of a doctor. Due to the possibility of developing addiction to the drug, it should be drunk according to a certain scheme. In the first 10-15 days, a dosage of up to 300 mg per day is used, divided into several doses. Further, the amount of the product should be reduced to 100 mg per day. Sometimes, to maintain the required vitamin level, during pregnancy it is enough to take 60 g, and during lactation - 80 g of ascorbic acid per day.

Ascorbic acid is injected intramuscularly and intravenously (slowly). For injections, a solution with a concentration of 5-10% is used. The dosage of ascorbic acid is 1-5 ml, depending on the indications. In case of poisoning, the dose can be increased to 60 mg (3 g). The duration of therapy is individual. Ascorbic acid in the form of vaginal tablets should be used once a day. The duration of therapy is usually 5 days.

note

Contraindications to taking ascorbic acid are hypersensitivity, a tendency to thrombosis, thrombophlebitis. The drug should be used with caution in diabetes mellitus, kidney problems and urolithiasis (including a history).

Possible side effects when taking high doses of vitamin C include headache, insomnia, and a sudden feeling of fatigue. Vomiting and nausea, stomach cramps, fever, skin reactions are possible.

Useful advice

You need to drink ascorbic acid after meals. 2 hours before and after oral intake of vitamin C, it is advisable not to consume alkaline drinks.

Ascorbic acid is a vitamin that is essential for the normal functioning of bone and connective tissue. It is not produced by the human body, therefore, it can only be obtained from outside: through food and when taking pharmaceutical preparations.

Instructions

With a deficiency of ascorbic acid (vitamin C), such as dryness and pallor of the skin, bleeding gums, brittle nails, rapid fatigue and weakening of the immune system appear in the body. In severe cases, a serious illness develops - scurvy, in which the blood vessels become so fragile that hemorrhages appear on the skin in the form of dark red spots. In addition, teeth begin to fall out and rheumatoid pains appear. Of course, it is not so easy to bring oneself to scurvy in modern life, but hypovitaminosis of a mild degree is quite common.

Take 50-100 mg of vitamin per day for malnutrition and to strengthen immunity during the cold season. Give your child half the dose. During and during lactation, the daily dose can be increased to 300 mg in the first week of administration, followed by a decrease in the dosage to 100 mg.

Take ascorbic acid after meals. In this case, the vitamin is well absorbed and has the most pronounced effect.

Consult your doctor before taking ascorbic acid if you have diabetes, kidney stones, or thrombophlebitis. If side effects appear (headache, rash, vomiting, diarrhea, etc.), stop the drug and consult a specialist to adjust the dose.

Do not drink vitamin C at the same time as heparin, aspirin, and hormonal contraceptives. In this case, the effectiveness of treatment is reduced.

The beneficial properties of vitamin C

Ascorbic acid is a powerful antioxidant that plays an important role in redox processes. Vitamin C is essential for the formation of collagen, serotonin, neurotransmitters (adrenaline, norepinephrine, dopamine), iron synthesis and metabolism.

In addition, vitamin C regulates blood clotting, participates in the process of hematopoiesis, increases the elasticity and strength of blood vessel walls, increases resistance to infections, lowers cholesterol levels, has an anti-allergic effect, and removes mercury and lead from the body. A sufficient level of ascorbic acid in the body contributes to greater stability and absorption of vitamin A, vitamin E, B vitamins and calcium.

Vitamin C against cancer

According to some medical research, ascorbic acid also has anti-cancer activity. In particular, the antitumor effect of vitamin C was noted in malignant diseases of the urinary, brain, pancreas, mucous membranes, ovaries, colon and esophagus.

As the researchers note, to obtain an anti-cancer effect, ascorbic acid must be administered intravenously at a dose of 200 mg or more per day. Moreover, this method of treatment is by no means the main one in the treatment of oncological diseases. Vitamin C treatment is recommended to be used as a supplement to the traditional one.

Vitamin C intake

Since the human body is unable to synthesize acid, it must come from food. An adult needs 90 mg of vitamin C daily, pregnant women - 100 mg of vitamin C, nursing mothers - 120 mg of vitamin C, children - from 30 to 90 mg of vitamin C, depending on age. Smokers and people experiencing intense physical and emotional stress, it is advisable to consume up to 125 mg of vitamin C per day. The elderly and women taking oral contraceptives also need higher doses of ascorbic acid.

Sources of Vitamin C

The record holders for the content of ascorbic acid are rose hips, black currants, spinach, red bell peppers and parsley. In addition, the following berries, vegetables and fruits are rich in vitamin C: sea buckthorn, lingonberries, garden strawberries, gooseberries, raspberries, red currants, sorrel, horseradish, tomatoes, green bell peppers, radishes, green onions, freshly picked potatoes, cauliflower, white cabbage, Brussels sprouts, green peas, oranges, lemons, tangerines, melon, apples, kiwi. Since ascorbic acid is destroyed during the heat treatment of food, the above products are best consumed fresh.